Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites

BACKGROUND: Macrophages and their precursors monocytes play a key role in inflammation and chronic inflammatory disorders. Monocyte-to-macrophage differentiation and activation programs are accompanied by significant epigenetic remodeling where DNA methylation associates with cell identity. Here we...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Dekkers, Koen F., Neele, Annette E., Jukema, J. Wouter, Heijmans, Bastiaan T., de Winther, Menno P. J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551876/
https://ncbi.nlm.nih.gov/pubmed/31171035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-019-0279-4
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