SAT-339 Cross-Talk with Breast Adipose Tissue Contributes to Obesity-induced DNA Damage in BRCA Mutant Breast Epithelial Cells

Background: Obese women who carry a mutation in the DNA repair enzymes BRCA1 and/or BRCA2 are at a greater risk of developing breast cancer compared with lean BRCA1/2 mutation carriers. Causative factors that drive the increased penetrance of breast cancer in obese women are poorly characterized. Pr...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Bhardwaj, Priya, Iyengar, Neil, Oshchepkova, Sofya, Bareja, Rohan, Dannenberg, Andrew, Elemento, Olivier, Morrow, Monica, Spector, Jason, Brown, Kristy
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2019
Assuntos:
Tumor Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551671/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-SAT-339
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