Caffeine inhibits PI3K and mTORC2 in Dictyostelium and differentially affects multiple other cAMP chemoattractant signaling effectors.

Caffeine is commonly used in Dictyostelium to inhibit the synthesis of the chemoattractant cAMP and, therefore, its secretion and the autocrine stimulation of cells, in order to prevent its interference with the study of chemoattractant-induced responses. However, the mechanism through which caffein...

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Bibliographic Details
Published in:Mol Cell Biochem
Main Authors: Islam, A.F.M. Tariqul, Scavello, Margarethakay, Lotfi, Pouya, Daniel, Dustin, Haldeman, Pearce, Charest, Pascale G.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551265/
https://ncbi.nlm.nih.gov/pubmed/30879206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-019-03520-z
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