MON-538 Ca(2+)Allostery in PTH-Receptor Signaling

The parathyroid hormone (PTH) type 1 receptor (PTHR) serves as the cognate receptor for two endogenous ligands, PTH and its related peptide (PTHrP). Binding of PTHrP to the PTHR results in only transient cAMP production that is limited to the plasma membrane, while PTH induces sustained cAMP respons...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: White, Alex, Sutkeviciute, Ieva, Jean-Alphonse, Frederic, Xiao, Kunhong, Vilardaga, Jean-Pierre
Format: Artigo
Language:Inglês
Published: Endocrine Society 2019
Subjects:
Bone and Mineral Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551044/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-MON-538
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