MON-484 Adipocyte-Specific GH Receptor Knockout Mice (AdGHRKO) Have Enhanced Insulin Sensitivity with Reduced Liver Triglycerides and Depot Specific Analyses in These Mice Suggest that GH May Have a More Substantial Effect on Subcutaneous White Adipose Tissue (WAT) Than Other WAT Depots

Global GH receptor “knockout” (GHRKO) mice have enhanced insulin sensitivity despite obesity, with a disproportionate increase in subcutaneous white adipose tissue (WAT). To better understand the direct effects of GH on WAT, we previously generated Fat-specific GHR knockout (FaGHRKO) mice using the...

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Dettagli Bibliografici
Pubblicato in:J Endocr Soc
Autori principali: List, Edward, Berryman, Darlene, Funk, Kevin, Bell, Stephen, Duran Ortiz, Silvana, Young, Jonathan, Jensen, Elizabeth, Qian, Yanrong, Julie, Slyby, McKenna, Savannah, Kopchick, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2019
Soggetti:
Neuroendocrinology and Pituitary
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550893/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-MON-484
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