Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A(2)α

Ca(2+)-stimulated translocation of cytosolic phospholipase A(2)α (cPLA(2)α) to the Golgi induces arachidonic acid production, the rate-limiting step in pro-inflammatory eicosanoid synthesis. Structural insights into the cPLA(2)α preference for phosphatidylcholine (PC)-enriched membranes have remaine...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Hirano, Yoshinori, Gao, Yong-Guang, Stephenson, Daniel J, Vu, Ngoc T, Malinina, Lucy, Simanshu, Dhirendra K, Chalfant, Charles E, Patel, Dinshaw J, Brown, Rhoderick E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550875/
https://ncbi.nlm.nih.gov/pubmed/31050338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44760
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