MON-187 The E23K Missense Variant of the Gene Encoding the Pancreatic Beta-Cell KATP Channel Subunit Kir6.2 (KCNJ11) Associates with Diabetic Retinopathy and Hyperglycemia Control in Type 2 Diabetes Patients

BACKGROUND. The ATP-sensitive K (K(ATP)) channel regulates insulin sensitivity, by linking insulin secretion to changes in blood glucose levels. HYPOTHESIS. Kir6.2 is a specific point mutation in KCNJ11 gene, which encodes the pore-forming subunit of the pancreatic K(ATP) channel, and was reportedly...

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Vydáno v:J Endocr Soc
Hlavní autoři: Sarray, Sameh, Almawi, Wassim
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2019
Témata:
Diabetes Mellitus and Glucose Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550821/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-MON-187
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