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Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2–SUR1 interactions

ATP-sensitive K(+) (K(ATP)) channels, comprised of pore-forming Kir6.2 and regulatory SUR1 subunits, play a critical role in regulating insulin secretion. Binding of ATP to Kir6.2 inhibits, whereas interaction of MgATP with SUR1 activates, K(ATP) channels. We tested the functional effects of two Kir...

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Hlavní autoři: Tammaro, Paolo, Girard, Christophe, Molnes, Janne, Njølstad, Pål R, Ashcroft, Frances M
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1173155/
https://ncbi.nlm.nih.gov/pubmed/15962003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600715
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