MON-203 Local Activation of 11-Oxygenated Androgens by AKR1C3 Is the Predominant Source of Androgens in Human Female Adipose Tissue

Polycystic ovary syndrome (PCOS) affects 10% of women and is a lifelong metabolic disorder, with increased risk of type 2 diabetes, fatty liver and cardiovascular disease. Androgen excess is an important driver of metabolic risk. Excess androgen activation in adipose tissue from PCOS women, through...

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Bibliografiske detaljer
Udgivet i:J Endocr Soc
Main Authors: Schiffer, Lina, Sinclair, Alexandra, Ludwig, Christian, O'Reilly, Michael, Westgate, Connar, Singhal, Rishi, Taylor, Angela, Dunn, Warwick, Arlt, Wiebke, Storbeck, Karl-Heinz
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2019
Fag:
Reproductive Endocrinology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550723/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-MON-203
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