Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish

Somatic loss-of-function mutations of the additional sex combs-like transcriptional regulator 1 (ASXL1) gene are common genetic abnormalities in human myeloid malignancies and induce clonal expansion of mutated hematopoietic stem cells (HSCs). To understand how ASXL1 disruption leads to myeloid cell...

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Udgivet i:Dis Model Mech
Main Authors: Gjini, Evisa, Jing, Chang-Bin, Nguyen, Ashley T., Reyon, Deepak, Gans, Emma, Kesarsing, Michiel, Peterson, Joshua, Pozdnyakova, Olga, Rodig, Scott J., Mansour, Marc R., Joung, Keith, Look, A. Thomas
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550042/
https://ncbi.nlm.nih.gov/pubmed/31064769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.035790
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