Proteostasis and ALS: protocol for a phase II, randomised, double-blind, placebo-controlled, multicentre clinical trial for colchicine in ALS (Co-ALS)

INTRODUCTION: Disruptions of proteasome and autophagy systems are central events in amyotrophic lateral sclerosis (ALS) and support the urgent need to find therapeutic compounds targeting these processes. The heat shock protein B8 (HSPB8) recognises and promotes the autophagy-mediated removal of mis...

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Bibliografiske detaljer
Udgivet i:BMJ Open
Main Authors: Mandrioli, Jessica, Crippa, Valeria, Cereda, Cristina, Bonetto, Valentina, Zucchi, Elisabetta, Gessani, Annalisa, Ceroni, Mauro, Chio, Adriano, D’Amico, Roberto, Monsurrò, Maria Rosaria, Riva, Nilo, Sabatelli, Mario, Silani, Vincenzo, Simone, Isabella Laura, Sorarù, Gianni, Provenzani, Alessandro, D’Agostino, Vito Giuseppe, Carra, Serena, Poletti, Angelo
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2019
Fag:
Neurology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549675/
https://ncbi.nlm.nih.gov/pubmed/31152038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2018-028486
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