Proteostasis and ALS: protocol for a phase II, randomised, double-blind, placebo-controlled, multicentre clinical trial for colchicine in ALS (Co-ALS)

INTRODUCTION: Disruptions of proteasome and autophagy systems are central events in amyotrophic lateral sclerosis (ALS) and support the urgent need to find therapeutic compounds targeting these processes. The heat shock protein B8 (HSPB8) recognises and promotes the autophagy-mediated removal of mis...

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Detalles Bibliográficos
Publicado en:BMJ Open
Autores principales: Mandrioli, Jessica, Crippa, Valeria, Cereda, Cristina, Bonetto, Valentina, Zucchi, Elisabetta, Gessani, Annalisa, Ceroni, Mauro, Chio, Adriano, D’Amico, Roberto, Monsurrò, Maria Rosaria, Riva, Nilo, Sabatelli, Mario, Silani, Vincenzo, Simone, Isabella Laura, Sorarù, Gianni, Provenzani, Alessandro, D’Agostino, Vito Giuseppe, Carra, Serena, Poletti, Angelo
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2019
Materias:
Neurology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549675/
https://ncbi.nlm.nih.gov/pubmed/31152038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2018-028486
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