Oncogenic KRAS signaling activates mTORC1 through COUP‐TFII‐mediated lactate production

Oncogenic signals contribute to enhanced glycolysis and mTORC1 activity, leading to rapid cell proliferation in cancer. Regulation of glycolysis and mTORC1 by PI3K/Akt signaling is well established, but how KRAS‐induced MEK signaling regulates these pathways remains poorly understood. Here, we repor...

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Dettagli Bibliografici
Pubblicato in:EMBO Rep
Autori principali: Byun, Jun‐Kyu, Park, Mihyang, Yun, Jae Won, Lee, Jaebon, Kim, Jae Sun, Cho, Sung Jin, Lee, You Mie, Lee, In‐Kyu, Choi, Yeon‐Kyung, Park, Keun‐Gyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Scientific Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549031/
https://ncbi.nlm.nih.gov/pubmed/30988000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201847451
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