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Oncogenic KRAS signaling activates mTORC1 through COUP‐TFII‐mediated lactate production
Oncogenic signals contribute to enhanced glycolysis and mTORC1 activity, leading to rapid cell proliferation in cancer. Regulation of glycolysis and mTORC1 by PI3K/Akt signaling is well established, but how KRAS‐induced MEK signaling regulates these pathways remains poorly understood. Here, we repor...
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| Publicado no: | EMBO Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6549031/ https://ncbi.nlm.nih.gov/pubmed/30988000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201847451 |
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