Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin

Tissue transglutaminase (TG2) is a multi-functional protein, with enzymatic, GTP-ase and scaffold properties. TG2 interacts with fibronectin (FN) through its N-terminus domain, stabilizing integrin complexes, which regulate cell adhesion to the matrix. Through this mechanism, TG2 participates in key...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Sima, Livia Elena, Yakubov, Bakhtiyor, Zhang, Sheng, Condello, Salvatore, Grigorescu, Arabela A., Nwani, Nkechiyere G., Chen, Lan, Schiltz, Gary E., Arvanitis, Constandina, Zhang, Zhong-Yin, Matei, Daniela
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548576/
https://ncbi.nlm.nih.gov/pubmed/31015308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1148
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