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Overcoming BET inhibitor resistance in malignant peripheral nerve sheath tumors

PURPOSE: BET bromodomain inhibitors have emerged as a promising therapy for numerous cancer types in pre-clinical studies, including Neurofibromatosis Type 1 (NF1)-associated Malignant Peripheral Nerve Sheath Tumor (MPNST). However, potential mechanisms underlying resistance to these inhibitors in d...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Cooper, Jonathan M., Patel, Amish J., Chen, Zhiguo, Liao, Chung-Ping, Chen, Kun, Mo, Juan, Wang, Yong, Le, Lu Q.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548569/
https://ncbi.nlm.nih.gov/pubmed/30796033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2437
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