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Designer drugs for designer receptors: unlocking the translational potential of chemogenetics
Chemogenetic techniques allow selective manipulation of neurons by activating engineered actuator proteins with otherwise-inert effector molecules. A recent study describes the co-evolution of highly potent actuator-effector pairs based on a clinically approved anti-smoking drug. These tools allow s...
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| Publicado no: | Trends Pharmacol Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6548557/ https://ncbi.nlm.nih.gov/pubmed/31072638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2019.04.010 |
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