CBX2 is required to stabilize the testis pathway by repressing Wnt signaling

XX and XY fetal gonads are initially bipotential, poised between the ovary and testis fate. Multiple lines of evidence suggest that commitment to testis fate requires the repression of genes associated with ovary fate. It was previously shown that loss of CBX2, the subunit of the Polycomb Repressive...

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Udgivet i:PLoS Genet
Main Authors: Garcia-Moreno, S. Alexandra, Lin, Yi-Tzu, Futtner, Christopher R., Salamone, Isabella M., Capel, Blanche, Maatouk, Danielle M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548405/
https://ncbi.nlm.nih.gov/pubmed/31116734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007895
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