Increasing molar activity by HPLC purification improves (68)Ga-DOTA-NAPamide tumor accumulation in a B16/F1 melanoma xenograft model

PURPOSE: Melanocortin receptor 1 (MC1R) is overexpressed in melanoma and may be a molecular target for imaging and peptide receptor radionuclide therapy. (68)Gallium ((68)Ga) labeling of DOTA-conjugated peptides is an established procedure in the clinic for use in positron emission tomography (PET)...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: von Hacht, Jan Lennart, Erdmann, Sarah, Niederstadt, Lars, Prasad, Sonal, Wagener, Asja, Exner, Samantha, Beindorff, Nicola, Brenner, Winfried, Grötzinger, Carsten
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548402/
https://ncbi.nlm.nih.gov/pubmed/31163066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217883
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