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HDAC inhibitors rescue multiple disease-causing CFTR variants

Understanding the role of the epigenome in protein-misfolding diseases remains a challenge in light of genetic diversity found in the world-wide population revealed by human genome sequencing efforts and the highly variable response of the disease population to therapeutics. An ever-growing body of...

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Pubblicato in:Hum Mol Genet
Autori principali: Anglès, Frédéric, Hutt, Darren M, Balch, William E
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548347/
https://ncbi.nlm.nih.gov/pubmed/30753450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz026
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