Respiratory chain inactivation links cartilage-mediated growth retardation to mitochondrial diseases

In childhood, skeletal growth is driven by transient expansion of cartilage in the growth plate. The common belief is that energy production in this hypoxic tissue mainly relies on anaerobic glycolysis and not on mitochondrial respiratory chain (RC) activity. However, children with mitochondrial dis...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Holzer, Tatjana, Probst, Kristina, Etich, Julia, Auler, Markus, Georgieva, Veronika S., Bluhm, Björn, Frie, Christian, Heilig, Juliane, Niehoff, Anja, Nüchel, Julian, Plomann, Markus, Seeger, Jens M., Kashkar, Hamid, Baris, Olivier R., Wiesner, Rudolf J., Brachvogel, Bent
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2019
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548139/
https://ncbi.nlm.nih.gov/pubmed/31085560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201809056
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