BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors

CD4(+) T helper 17 (Th17) cells protect vertebrate hosts from extracellular pathogens at mucosal surfaces. Th17 cells form from naive precursors when signals from the T cell antigen receptor (TCR) and certain cytokine receptors induce the expression of the RORγt transcription factor, which activates...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: Kotov, Jessica A., Kotov, Dmitri I., Linehan, Jonathan L., Bardwell, Vivian J., Gearhart, Micah D., Jenkins, Marc K.
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2019
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547868/
https://ncbi.nlm.nih.gov/pubmed/31053612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182376
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