Evolution of replication origins in vertebrate genomes: rapid turnover despite selective constraints

The replication program of vertebrate genomes is driven by the chromosomal distribution and timing of activation of tens of thousands of replication origins. Genome-wide studies have shown the association of origins with promoters and CpG islands, and their enrichment in G-quadruplex motifs (G4). Ho...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Massip, Florian, Laurent, Marc, Brossas, Caroline, Fernández-Justel, José Miguel, Gómez, María, Prioleau, Marie-Noelle, Duret, Laurent, Picard, Franck
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547456/
https://ncbi.nlm.nih.gov/pubmed/30916335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz182
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