miR-122 and Ago interactions with the HCV genome alter the structure of the viral 5′ terminus

Hepatitis C virus (HCV) is a positive-sense RNA virus that interacts with the liver-specific microRNA, miR-122. miR-122 binds to two sites in the 5′ untranslated region (UTR) and this interaction promotes HCV RNA accumulation, although the precise role of miR-122 in the HCV life cycle remains unclea...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Chahal, Jasmin, Gebert, Luca F R, Gan, Hin Hark, Camacho, Edna, Gunsalus, Kristin C, MacRae, Ian J, Sagan, Selena M
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2019
Ämnen:
RNA and RNA-protein complexes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547439/
https://ncbi.nlm.nih.gov/pubmed/30941417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz194
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