BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells

BRCA1-associated basal-like breast cancer originates from luminal progenitor cells. Breast epithelial cells from cancer-free BRCA1 mutation carriers are defective in luminal differentiation. However, how BRCA1 deficiency leads to lineage-specific differentiation defect is not clear. BRCA1 is implica...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Chiang, Huai-Chin, Zhang, Xiaowen, Li, Jingwei, Zhao, Xiayan, Chen, Jerry, Wang, Howard T-H, Jatoi, Ismail, Brenner, Andrew, Hu, Yanfen, Li, Rong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Gene regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547407/
https://ncbi.nlm.nih.gov/pubmed/30982901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz262
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