BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells

BACKGROUND: BRCA1-associated breast cancer originates from luminal progenitor cells. BRCA1 functions in multiple biological processes, including double-strand break repair, replication stress suppression, transcriptional regulation, and chromatin reorganization. While non-malignant cells carrying ca...

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Библиографические подробности
Опубликовано в: :Breast Cancer Res
Главные авторы: Zhang, Xiaowen, Wang, Yao, Chiang, Huai-Chin, Hsieh, Yuan-Pang, Lu, Chang, Park, Ben Ho, Jatoi, Ismail, Jin, Victor X., Hu, Yanfen, Li, Rong
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472090/
https://ncbi.nlm.nih.gov/pubmed/30995943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-019-1132-1
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