Automated detection of the HER2 gene amplification status in Fluorescence in situ hybridization images for the diagnostics of cancer tissues

The human epidermal growth factor receptor 2 (HER2) gene amplification status is a crucial marker for evaluating clinical therapies of breast or gastric cancer. We propose a deep learning-based pipeline for the detection, localization and classification of interphase nuclei depending on their HER2 g...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Zakrzewski, Falk, de Back, Walter, Weigert, Martin, Wenke, Torsten, Zeugner, Silke, Mantey, Robert, Sperling, Christian, Friedrich, Katrin, Roeder, Ingo, Aust, Daniela, Baretton, Gustavo, Hönscheid, Pia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546913/
https://ncbi.nlm.nih.gov/pubmed/31160649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44643-z
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