Anti–neurofascin-155 IgG4 antibodies prevent paranodal complex formation in vivo

Neurofascin-155 (Nfasc155) is an essential glial cell adhesion molecule expressed in paranodal septate-like junctions of peripheral and central myelinated axons. The genetic deletion of Nfasc155 results in the loss of septate-like junctions and in conduction slowing. In humans, IgG4 antibodies again...

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Publicat a:J Clin Invest
Autors principals: Manso, Constance, Querol, Luis, Lleixà, Cinta, Poncelet, Mallory, Mekaouche, Mourad, Vallat, Jean-Michel, Illa, Isabel, Devaux, Jérôme J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546478/
https://ncbi.nlm.nih.gov/pubmed/30869655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124694
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