B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma

BACKGROUND. CAR T cells are a promising therapy for hematologic malignancies. B cell maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS. We conducted a phase I study of autologous T cells lentivirally transduced with a fully human, BCMA-specific CAR containing CD3ζ and...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Cohen, Adam D., Garfall, Alfred L., Stadtmauer, Edward A., Melenhorst, J. Joseph, Lacey, Simon F., Lancaster, Eric, Vogl, Dan T., Weiss, Brendan M., Dengel, Karen, Nelson, Annemarie, Plesa, Gabriela, Chen, Fang, Davis, Megan M., Hwang, Wei-Ting, Young, Regina M., Brogdon, Jennifer L., Isaacs, Randi, Pruteanu-Malinici, Iulian, Siegel, Don L., Levine, Bruce L., June, Carl H., Milone, Michael C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Clinical Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546468/
https://ncbi.nlm.nih.gov/pubmed/30896447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126397
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