B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma

BACKGROUND. CAR T cells are a promising therapy for hematologic malignancies. B cell maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS. We conducted a phase I study of autologous T cells lentivirally transduced with a fully human, BCMA-specific CAR containing CD3ζ and...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Cohen, Adam D., Garfall, Alfred L., Stadtmauer, Edward A., Melenhorst, J. Joseph, Lacey, Simon F., Lancaster, Eric, Vogl, Dan T., Weiss, Brendan M., Dengel, Karen, Nelson, Annemarie, Plesa, Gabriela, Chen, Fang, Davis, Megan M., Hwang, Wei-Ting, Young, Regina M., Brogdon, Jennifer L., Isaacs, Randi, Pruteanu-Malinici, Iulian, Siegel, Don L., Levine, Bruce L., June, Carl H., Milone, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546468/
https://ncbi.nlm.nih.gov/pubmed/30896447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126397
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