Osteopontin Promotes Left Ventricular Diastolic Dysfunction through a Mitochondrial Pathway

BACKGROUND: Patients with chronic kidney disease (CKD) and coincident heart failure with preserved ejection fraction (HFpEF) may constitute a distinct HFpEF phenotype. Osteopontin (OPN) is a biomarker of HFpEF and predictive of disease outcome. We recently reported that OPN blockade reversed hyperte...

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Detalhes bibliográficos
Publicado no:J Am Coll Cardiol
Main Authors: Yousefi, Keyvan, Irion, Camila I., Takeuchi, Lauro M., Ding, Wen, Lambert, Guerline, Eisenberg, Trevor, Sukkar, Sarah, Granzier, Hendrikus L., Methawasin, Mei, Lee, Dong I., Hahn, Virginia, Kass, David A., Hatzistergos, Konstantinos E., Hare, Joshua M., Webster, Keith A, Shehadeh, Lina A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546303/
https://ncbi.nlm.nih.gov/pubmed/31146816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2019.02.074
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