Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits

Alport syndrome is a rare hereditary renal disorder with no etiologic therapy. We found that osteopontin (OPN) is highly expressed in the renal tubules of the Alport mouse and plays a causative pathological role. OPN genetic deletion ameliorated albuminuria, hypertension, tubulointerstitial prolifer...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Ding, Wen, Yousefi, Keyvan, Goncalves, Stefania, Goldstein, Bradley J., Sabater, Alfonso L., Kloosterboer, Amy, Ritter, Portia, Lambert, Guerline, Mendez, Armando J., Shehadeh, Lina A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926939/
https://ncbi.nlm.nih.gov/pubmed/29563333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94818
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