ELMER v.2: an R/Bioconductor package to reconstruct gene regulatory networks from DNA methylation and transcriptome profiles

MOTIVATION: DNA methylation has been used to identify functional changes at transcriptional enhancers and other cis-regulatory modules (CRMs) in tumors and other disease tissues. Our R/Bioconductor package ELMER (Enhancer Linking by Methylation/Expression Relationships) provides a systematic approac...

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Pubblicato in:Bioinformatics
Autori principali: Silva, Tiago C, Coetzee, Simon G, Gull, Nicole, Yao, Lijing, Hazelett, Dennis J, Noushmehr, Houtan, Lin, De-Chen, Berman, Benjamin P
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
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Applications Notes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546131/
https://ncbi.nlm.nih.gov/pubmed/30364927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty902
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