Apical-basal polarity inhibits Epithelial-Mesenchymal Transition and tumour metastasis via PAR complex-mediated SNAI1 degradation

Loss of apical-basal polarity and activation of Epithelial-Mesenchymal Transition (EMT) both contribute to carcinoma progression and metastasis. Here, we report that apical-basal polarity inhibits EMT to suppress metastatic dissemination. Using mouse and human epithelial 3D organoid cultures, we sho...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Cell Biol
Main Authors: Jung, Hae-Yun, Fattet, Laurent, Tsai, Jeff H., Kajimoto, Taketoshi, Chang, Qiang, Newton, Alexandra C., Yang, Jing
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546105/
https://ncbi.nlm.nih.gov/pubmed/30804505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0291-8
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker