Apical-basal polarity inhibits Epithelial-Mesenchymal Transition and tumour metastasis via PAR complex-mediated SNAI1 degradation

Loss of apical-basal polarity and activation of Epithelial-Mesenchymal Transition (EMT) both contribute to carcinoma progression and metastasis. Here, we report that apical-basal polarity inhibits EMT to suppress metastatic dissemination. Using mouse and human epithelial 3D organoid cultures, we sho...

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Publicat a:Nat Cell Biol
Autors principals: Jung, Hae-Yun, Fattet, Laurent, Tsai, Jeff H., Kajimoto, Taketoshi, Chang, Qiang, Newton, Alexandra C., Yang, Jing
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546105/
https://ncbi.nlm.nih.gov/pubmed/30804505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0291-8
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