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Apical-basal polarity inhibits Epithelial-Mesenchymal Transition and tumour metastasis via PAR complex-mediated SNAI1 degradation
Loss of apical-basal polarity and activation of Epithelial-Mesenchymal Transition (EMT) both contribute to carcinoma progression and metastasis. Here, we report that apical-basal polarity inhibits EMT to suppress metastatic dissemination. Using mouse and human epithelial 3D organoid cultures, we sho...
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| Publicado no: | Nat Cell Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6546105/ https://ncbi.nlm.nih.gov/pubmed/30804505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0291-8 |
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