Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia

Germline RUNX1 mutations lead to thrombocytopenia and platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia (AML). Multiple aspects of platelet function are impaired in these patients, associated with altered expression of genes regulated by RUNX1. We a...

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Publicat a:Haematologica
Autors principals: Glembotsky, Ana C., Sliwa, Dominika, Bluteau, Dominique, Balayn, Nathalie, Marin Oyarzún, Cecilia P., Raimbault, Anna, Bordas, Marie, Droin, Nathalie, Pirozhkova, Iryna, Washington, Valance, Goette, Nora P., Marta, Rosana F., Favier, Rémi, Raslova, Hana, Heller, Paula G.
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6545826/
https://ncbi.nlm.nih.gov/pubmed/30545930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.188904
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