ロード中...

Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression

Proteins of the bromodomain and extra-terminal (BET) family are epigenetics “readers” and promising therapeutic targets for cancer and other human diseases. We describe herein a structure-guided design of 1,4-oxazepines as a new class of BET inhibitors and our subsequent design, synthesis and evalua...

詳細記述

保存先:
書誌詳細
出版年:J Med Chem
主要な著者: Qin, Chong, Hu, Yang, Zhou, Bing, Fernandez-Salas, Ester, Yang, Chao-Yie, Liu, Liu, McEachern, Donna, Przybranowski, Sally, Wang, Mi, Stuckey, Jeanne, Meagher, Jennifer, Bai, Longchuan, Chen, Zhuo, Lin, Mei, Yang, Jiuling, Xu, Fuming, Hu, Jiantao, Xing, Weiguo, Huang, Liyue, Li, Siwei, Wen, Bo, Sun, Duxin, Wang, Shaomeng
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6545111/
https://ncbi.nlm.nih.gov/pubmed/30019901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00506
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!