rSjp40 inhibits activated hepatic stellate cells by promoting nuclear translocation of YB1 and inducing BMP-7/Smad1/5/8 pathway

BACKGROUND: Activation of hepatic stellate cells is the dominant pathogenic event during the process of liver fibrosis. Bone morphogenic protein (BMP)-7 has recently been identified as an anti-fibrotic factor and leads to phosphorylation of Smad1/5/8 in activated hepatic stellate cells. Its expressi...

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Bibliographic Details
Published in:Parasit Vectors
Main Authors: Chen, Liuting, Zhou, Qi, Liu, Ertao, Zhang, Jiali, Duan, Lian, Zhu, Dandan, Chen, Jinling, Duan, Yinong
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6545069/
https://ncbi.nlm.nih.gov/pubmed/31151477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13071-019-3539-z
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