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A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers
Most cancer cells are dependent on a network of deregulated signaling pathways for survival and are insensitive, or rapidly evolve resistance, to selective inhibitors aimed at a single target. For these reasons, drugs that target more than one protein (polypharmacology) can be clinically advantageou...
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| Gepubliceerd in: | J Biol Chem |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Biochemistry and Molecular Biology
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6544847/ https://ncbi.nlm.nih.gov/pubmed/30858179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006805 |
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