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Performance Assessment and Selection of Normalization Procedures for Single-Cell RNA-Seq

Systematic measurement biases make normalization an essential step in single-cell RNA sequencing (scRNA-seq) analysis. There may be multiple competing considerations behind the assessment of normalization performance, of which some may be study specific. We have developed “scone”— a flexible framewo...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Cole, Michael B., Risso, Davide, Wagner, Allon, DeTomaso, David, Ngai, John, Purdom, Elizabeth, Dudoit, Sandrine, Yosef, Nir
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544759/
https://ncbi.nlm.nih.gov/pubmed/31022373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.03.010
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