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Can Predicted Protein 3D Structures Provide Reliable Insights into whether Missense Variants Are Disease Associated?

Knowledge of protein structure can be used to predict the phenotypic consequence of a missense variant. Since structural coverage of the human proteome can be roughly tripled to over 50% of the residues if homology-predicted structures are included in addition to experimentally determined coordinate...

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Библиографические подробности
Опубликовано в: :J Mol Biol
Главные авторы: Ittisoponpisan, Sirawit, Islam, Suhail A., Khanna, Tarun, Alhuzimi, Eman, David, Alessia, Sternberg, Michael J.E.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544567/
https://ncbi.nlm.nih.gov/pubmed/30995449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.04.009
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