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Pathogenicity of the H1N1 influenza virus enhanced by functional synergy between the NP(V100I) and NA(D248N) pair

By comparing and measuring covariations of viral protein sequences from isolates of the 2009 pH1N1 influenza A virus (IAV), specific substitutions that co-occur in the NP-NA pair were identified. To investigate the effect of these co-occurring substitution pairs, the V100I substitution in NP and the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kim, Woo-Jong, Hur, Kye-Yeon, Park, Han Wook, Lee, Seung-Woo, Yoo, Joo-Yeon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544299/
https://ncbi.nlm.nih.gov/pubmed/31150476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217691
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