Development and validation of a multiplex UHPLC-MS/MS method for the determination of the investigational antibiotic against multi-resistant tuberculosis macozinone (PBTZ169) and five active metabolites in human plasma

The emergence of Mycobacterium tuberculosis strains resistant to current first-line antibiotic regimens constitutes a major global health threat. New treatments against multidrug-resistant tuberculosis (MDR-TB) are thus eagerly needed in particular in countries with a high MDR-TB prevalence. In this...

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Publicat a:PLoS One
Autors principals: Spaggiari, Dany, Desfontaine, Vincent, Cruchon, Sandra, Guinchard, Sylvie, Vocat, Anthony, Blattes, Emilyne, Pitteloud, Jeff, Ciullini, Lorenzo, Bardinet, Carine, Ivanyuk, Anton, Makarov, Vadim, Ryabova, Olga, Buclin, Thierry, Cole, Stewart T., Decosterd, Laurent A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544242/
https://ncbi.nlm.nih.gov/pubmed/31150423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217139
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