Breaking Glucose Transporter 1/Pyruvate Kinase M2 Glycolytic Loop Is Required for Cantharidin Inhibition of Metastasis in Highly Metastatic Breast Cancer

Aerobic glycolysis plays a decisive role in cancer growth. However, its role in cancer metastasis was rarely understood. Cantharidin a natural compound from an arthropod insect cantharis exerts potent anticancer activity. Here we found cantharidin possesses significant anti-metastatic activity on br...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Pan, Yanhong, Zheng, Qian, Ni, Wenting, Wei, Zhonghong, Yu, Suyun, Jia, Qi, Wang, Meng, Wang, Aiyun, Chen, Wenxing, Lu, Yin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544055/
https://ncbi.nlm.nih.gov/pubmed/31178738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00590
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