Pulmonary Neuroendocrine Cells Secrete γ-Aminobutyric Acid to Induce Goblet Cell Hyperplasia in Primate Models

Mucus overproduction is a major contributor to morbidity and mortality in asthma. Mucus overproduction is induced by orchestrated actions of multiple factors that include inflammatory cytokines and γ-aminobutyric acid (GABA). GABA is produced only by pulmonary neuroendocrine cells (PNECs) in the mou...

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Bibliografske podrobnosti
izdano v:Am J Respir Cell Mol Biol
Main Authors: Barrios, Juliana, Kho, Alvin T., Aven, Linh, Mitchel, Jennifer A., Park, Jin-Ah, Randell, Scott H., Miller, Lisa A., Tantisira, Kelan G., Ai, Xingbin
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2019
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6543741/
https://ncbi.nlm.nih.gov/pubmed/30571139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2018-0179OC
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