Potential Mechanism for HIV-Associated Depression: Upregulation of Serotonin Transporters in SIV-Infected Macaques Detected by 11C-DASB PET

Purpose: Increased incidence of depression in HIV+ patients is associated with lower adherence to treatment and increased morbidity/mortality. One possible underlying pathophysiology is serotonergic dysfunction. In this study, we used an animal model of HIV, the SIV-infected macaque, to longitudinal...

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Veröffentlicht in:Front Psychiatry
Hauptverfasser: Shah, Swati, Sinharay, Sanhita, Matsuda, Kenta, Schreiber-Stainthorp, William, Muthusamy, Siva, Lee, Dianne, Wakim, Paul, Hirsch, Vanessa, Nath, Avindra, Di Mascio, Michele, Hammoud, Dima A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Psychiatry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6543249/
https://ncbi.nlm.nih.gov/pubmed/31178771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fpsyt.2019.00362
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