Aurone derivatives as Vps34 inhibitors that modulate autophagy

We report in this study the identification of a natural product-like antagonist (1a) of Vps34 as a potent autophagy modulator via structure-based virtual screening. Aurone derivative 1a strongly inhibited Vps34 activity in cell-free and cell-based assays. Significantly, 1a prevents autophagy in huma...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Acta Pharm Sin B
Main Authors: Li, Guodong, Boyle, Joshua William, Ko, Chung-Nga, Zeng, Wu, Wong, Vincent Kam Wai, Wan, Jian-Bo, Chan, Philip Wai Hong, Ma, Dik-Lung, Leung, Chung-Hang
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2019
Teme:
Original article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6543056/
https://ncbi.nlm.nih.gov/pubmed/31193773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.01.016
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