Ring Opening of Epoxides with [(18)F]FeF Species to Produce [(18)F]Fluorohydrin PET Imaging Agents

A simple technique for the preparation of [(18)F]HF has been developed and applied to the generation of an [(18)F]FeF species for opening sterically hindered epoxides. This method has been successfully employed to prepare four drug-like molecules, including 5-[(18)F]fluoro-6-hydroxy-cholesterol, a p...

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Udgivet i:Chem Commun (Camb)
Main Authors: Verhoog, Stefan, Brooks, Allen F., Winton, Wade P., Viglianti, Benjamin L., Sanford, Melanie S., Scott, Peter. J. H.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542722/
https://ncbi.nlm.nih.gov/pubmed/31062010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc02779c
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