TLR9/MyD88/TRIF signaling activates host immune inhibitory CD200 in Leishmania infection

Virulent protozoans named Leishmania in tropical and subtropical areas produce devastating diseases by exploiting host immune responses. Amastigotes of Leishmania amazonensis stimulate macrophages to express CD200, an immunomodulatory ligand, which binds to its cognate receptor (CD200R) and inhibits...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Sauter, Ismael P., Madrid, Katerine G., de Assis, Josiane B., Sá-Nunes, Anderson, Torrecilhas, Ana C., Staquicini, Daniela I., Pasqualini, Renata, Arap, Wadih, Cortez, Mauro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542632/
https://ncbi.nlm.nih.gov/pubmed/31092731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126207
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