TLR9/MyD88/TRIF signaling activates host immune inhibitory CD200 in Leishmania infection

Virulent protozoans named Leishmania in tropical and subtropical areas produce devastating diseases by exploiting host immune responses. Amastigotes of Leishmania amazonensis stimulate macrophages to express CD200, an immunomodulatory ligand, which binds to its cognate receptor (CD200R) and inhibits...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Sauter, Ismael P., Madrid, Katerine G., de Assis, Josiane B., Sá-Nunes, Anderson, Torrecilhas, Ana C., Staquicini, Daniela I., Pasqualini, Renata, Arap, Wadih, Cortez, Mauro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542632/
https://ncbi.nlm.nih.gov/pubmed/31092731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126207
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